They wrote that about half of the patients treated with ceftazidime-avibactam and about half of those treated with comparators were treated successfully.īoth groups had similar adverse events and they were consistent with the known safety profile of ceftazidime-avibactam, investigators.Gram-negative bacteria have different cell wall than Gram positive bacteria. The investigators also found a favorable microbiological response for those patients with ceftazidime-susceptible isolates.
#Gram negative bacteria plus#
9 of 11 patients treated with ceftazidimeavibactam plus metronidazole for cIAI reached a clinical cure while 9 out of 10 on the comparator did.Patients treated with ceftazidime-avibactam had a “generally similar” microbiological response rates at test-of-cure visit to those who received comparators. The most common primary diagnoses (acute pyelonephritis and VAP) and the most frequently isolated pathogens ( Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, among the top 3) were consistent across the studies, investigators wrote. The study authors also said 54 patients were in the gram-negative extended microbiologically evaluable (GNeME) subset and treated with ceftazidime-avibactam, while 47 GNeME patients received comparators. If a patient received 1 or more dose of study treatment, they were included in the analysis, the study authors explained.Īll 5 studies contained a total population of 3172 patients, of which 1855 received ceftazidime-avibactam and 1857 received comparators. They examined the safety outcomes as well, including adverse events and clinical lab assessments through the last patient visit. The investigators measured efficacy using clinical and microbiological responses at a test-of-cure visit, which was timed according to the protocols of each of the 5 studies.
In a majority of the studies, the comparators were carbapenems the patients with cIAI were treated with ceftazidime-avibactam plus metronidazole. The treatment durations varied in each of the studies. In each of the trials the study authors reviewed, patients were randomized to receive either intravenous ceftazidime-avibactam or comparators for between 5-21 days. The agency believes their “aggressive recommendations” can prevent the spread of gram-negatives. Additionally, they can pass along genetic material that can allow other bacteria to also become resistant to drugs. Investigators from the US, Germany, Spain, and the UK reviewed 5 randomized, controlled, multi-center phase 3 trials in adults with complicated intra-abdominal infection (cIAI), complicated urinary tract infection (cUTI), hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) - all infections caused by ceftazidime non-susceptible and multidrug-resistant gram-negative bacteria.Īccording to the US Centers for Disease Control and Prevention (CDC), Gram-negative bacteria can cause infections, are resistant to multiple drugs, and are increasingly resistant to most available antibiotics. Ceftazidime-avibactam was safe and effective for patients with a variety of gram-negative bacterial infections, according to an abstract planned for presentation at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2020 Meeting this year.